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Thursday, October 27, 2016

Propranolol HCl Intensol

Generic Name: propranolol (Oral route)

proe-PRAN-oh-lol

Oral route(Capsule, Extended Release)

Reports of exacerbation of angina and myocardial infarction have been noted following abrupt discontinuance of propranolol. When discontinuance of propranolol is planned, dosage should be gradually reduced over at least a few weeks, and the patient should be cautioned against interruption or cessation of therapy. If propranolol therapy is interrupted and exacerbation of angina occurs, reinstitution of propranolol and management of angina is advised. Since coronary artery disease may be unrecognized, it may be prudent to follow the above advice in patients considered at risk of having occult atherosclerotic heart disease who are given propranolol for other indications .

Commonly used brand name(s)

In the U.S.

Inderal

Inderal LA

InnoPran XL

Propranolol HCl Intensol

Available Dosage Forms:

Tablet

Capsule, Extended Release

Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Beta-Adrenergic Blocker, Nonselective

Uses For Propranolol HCl Intensol

Propranolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Propranolol is also used to treat severe chest pain (angina), migraine headaches, or hypertrophic subaortic stenosis (thickened heart muscle).

This medicine may also be used to treat irregular heartbeats, tremors, or pheochromocytoma (adrenal gland tumor). It may also be used to reduce the risk of death in patients who have heart attacks.

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

This medicine is available only with your doctor's prescription.

Before Using Propranolol HCl Intensol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propranolol capsules, extended-release capsules, and tablets in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of propranolol oral solution in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propranolol in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving propranolol.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Albuterol

Amiodarone

Arformoterol

Bambuterol

Bitolterol

Broxaterol

Bupivacaine

Clenbuterol

Clonidine

Colterol

Diatrizoate

Diltiazem

Dronedarone

Epinephrine

Fenoldopam

Fenoterol

Formoterol

Haloperidol

Hexoprenaline

Indacaterol

Isoetharine

Levalbuterol

Lidocaine

Mefloquine

Mepivacaine

Metaproterenol

Pirbuterol

Prilocaine

Procaterol

Reproterol

Rimiterol

Ritodrine

Salmeterol

Terbutaline

Tretoquinol

Tulobuterol

Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetohexamide

Alclofenac

Alfuzosin

Aluminum Carbonate, Basic

Aluminum Hydroxide

Aluminum Phosphate

Amlodipine

Apazone

Arbutamine

Benfluorex

Benoxaprofen

Bromfenac

Bufexamac

Bunazosin

Calcium Carbonate

Carprofen

Chlorpromazine

Chlorpropamide

Cimetidine

Clometacin

Clonixin

Dexketoprofen

Diclofenac

Diflunisal

Digoxin

Dihydroergotamine

Dihydroxyaluminum Aminoacetate

Dihydroxyaluminum Sodium Carbonate

Dipyrone

Disopyramide

Doxazosin

Droxicam

Ergotamine

Etodolac

Etofenamate

Felbinac

Felodipine

Fenbufen

Fenoprofen

Fentiazac

Flecainide

Floctafenine

Flufenamic Acid

Flurbiprofen

Fluvoxamine

Gliclazide

Glimepiride

Glipizide

Gliquidone

Glyburide

Guar Gum

Guggul

Ibuprofen

Indomethacin

Indoprofen

Insulin

Insulin Aspart, Recombinant

Insulin Glulisine

Insulin Lispro, Recombinant

Isoxicam

Ketoprofen

Ketorolac

Lacidipine

Lercanidipine

Lornoxicam

Magaldrate

Manidipine

Meclofenamate

Mefenamic Acid

Meloxicam

Metformin

Mibefradil

Miglitol

Moxisylyte

Nabumetone

Naproxen

Nicardipine

Nifedipine

Niflumic Acid

Nilvadipine

Nimesulide

Nimodipine

Nisoldipine

Nitrendipine

Oxaprozin

Oxyphenbutazone

Phenoxybenzamine

Phentolamine

Phenylbutazone

Phenylephrine

Piperine

Pirazolac

Piroxicam

Pirprofen

Pranidipine

Prazosin

Propoxyphene

Propyphenazone

Proquazone

Quinidine

Repaglinide

Rifapentine

Rizatriptan

Sertraline

St John's Wort

Sulindac

Suprofen

Tamsulosin

Tenidap

Tenoxicam

Terazosin

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolmetin

Trimazosin

Troglitazone

Tubocurarine

Urapidil

Zileuton

Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Proper Use of propranolol

This section provides information on the proper use of a number of products that contain propranolol. It may not be specific to Propranolol HCl Intensol. Please read with care.

Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the long-acting oral capsules whole. Do not chew, crush, or open them.

Propranolol extended-release capsules should be taken at bedtime (10 p.m.). This medicine may be taken with or without food. However, you should take it the same way each time.

Measure the concentrated oral solution, Intensol™ with the dropper that comes with the medicine. You may mix the concentrated solution with water, juice, soda, applesauce, or pudding to make it easier to swallow, then take the mixture right away.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute heart attack:
- For oral dosage form (solution):
  - Adults—180 to 240 milligrams (mg) per day, given in divided doses.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 40 milligrams (mg) three times a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

For adrenal gland tumor (pheochromocytoma):
- For oral dosage form (solution):
  - Adults—60 milligrams (mg) per day, given in divided doses for 3 days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—60 milligrams (mg) per day, given in divided doses for 3 days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.
  - Children—Use and dose must be determined by your doctor.

For chest pain (angina):
- For oral dosage form (long-acting oral capsules):
  - Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—80 to 320 milligrams (mg) per day, given in divided doses.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—80 to 320 milligrams (mg) per day, given in divided doses.
  - Children—Use and dose must be determined by your doctor.

For high blood pressure (hypertension):
- For oral dosage form (extended-release capsules):
  - Adults—At first, 80 milligrams (mg) once a day, given at bedtime. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (long-acting oral capsules):
  - Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

For hypertrophic subaortic stenosis (thickened heart muscle):
- For oral dosage form (long-acting oral capsules):
  - Adults—80 to 160 milligrams (mg) once a day.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Use and dose must be determined by your doctor.

For irregular heartbeats:
- For oral dosage form (solution):
  - Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Use and dose must be determined by your doctor.

For migraine headaches:
- For oral dosage form (long-acting oral capsules):
  - Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose if needed.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

For tremors:
- For oral dosage form (solution):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Propranolol HCl Intensol

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. .

Propranolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. Do not stop taking this medicine before surgery without your doctor's approval.

This medicine may cause some people to become less alert than they are normally. If this side effect occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert while taking propranolol.

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, or white spots in your mouth or lips; or unusual tiredness or weakness.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Propranolol will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system and may cause drowsiness. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Propranolol HCl Intensol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain and tenderness

black, tarry stools

blistering, peeling, or loosening of the skin

blood in the urine

bloody nose

bloody stools

blurred or loss of vision

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

confusion about identity, place, and time

congestion

constipation

cough

cracks in the skin

crying

decreased awareness or responsiveness

decreased urine output

depersonalization

diarrhea

difficulty with breathing or swallowing

difficulty with swallowing

dilated neck veins

disturbed color perception

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

dryness or soreness of the throat

dysphoria

euphoria

extreme fatigue

fast, pounding, slow, or irregular heartbeat

fever and chills

general feeling of discomfort, illness, or weakness

hair loss

halos around lights

headaches

heavier menstrual periods

hives

hoarseness

irregular breathing

itching

lightheadedness, dizziness, or fainting

loss of heat from the body

mental depression

mimicry of speech or movements

muscle or joint pain

mutism

nausea

negativism

night blindness

noisy breathing

overbright appearance of lights

paleness or cold feeling in the fingertips and toes

paranoia

peculiar postures or movements, mannerisms, or grimacing

pinpoint red or purple spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

quick to react or overreact emotionally

rapidly changing moods

rectal bleeding

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

reddening of the skin, especially around the ears

runny nose

scaly skin

seeing, hearing, or feeling things that are not there

severe sleepiness

short-term memory loss

shortness of breath

skin irritation or rash, including rash that looks like psoriasis

skin rash

sores, ulcers, or white spots in the mouth or on the lips

sweating

swelling of the eyes, face, fingers, feet, or lower legs

swollen glands

tender, swollen glands in the neck

tightness in the chest

tingling or pain in fingers or toes when exposed to cold

trouble with swallowing

troubled breathing

tunnel vision

unusual bleeding or bruising

unusual tiredness or weakness

voice changes

vomiting

weight gain

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Dry eyes

heartburn

loss of strength or energy

muscle weakness

pain or discomfort in the chest, upper stomach, or throat

sleeplessness

stomach cramps

trouble sleeping

unable to sleep

unusual drowsiness, dullness, or feeling of sluggishness

vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Propranolol HCl Intensol side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More Propranolol HCl Intensol resources

Propranolol HCl Intensol Side Effects (in more detail)
Propranolol HCl Intensol Use in Pregnancy & Breastfeeding
Drug Images
Propranolol HCl Intensol Drug Interactions
Propranolol HCl Intensol Support Group
90 Reviews for Propranolol HCl Intensol - Add your own review/rating

Compare Propranolol HCl Intensol with other medications

Angina
Aortic Stenosis
Arrhythmia
Benign Essential Tremor
Heart Attack
Hemangioma
High Blood Pressure
Migraine Prevention
Mitral Valve Prolapse
Performance Anxiety
Pheochromocytoma
Tardive Dyskinesia
Thyrotoxicosis

Pedia-Lax

Generic Name: senna (SEN nah)

Brand Names: Black Draught, Dr Caldwell Laxative, Ex-Lax Chocolated, Ex-Lax Maximum Relief Formula, Ex-Lax Regular Strength Pills, Fletchers Castoria, Innerclean, Pedia-Lax, Perdiem Overnight, Senexon, Senna, Senna Lax, Senna Smooth, Senna Soft, Senna-gen, Senokot, Senokot Extra, SenokotXTRA, SenoSol, SenoSol-X

What is Pedia-Lax (senna)?

Senna is also known as Cassia senna, tinnevelly senna, India senna, Alexandrian senna, and Khartoum senna.

Senna has been used in alternative medicine as an aid to treat constipation.

Not all uses for senna have been approved by the FDA. Senna should not be used in place of medication prescribed for you by your doctor.

Senna is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Senna may also be used for other purposes not listed in this product guide.

What is the most important information I should know about Pedia-Lax (senna)?

Not all uses for senna have been approved by the FDA. Senna should not be used in place of medication prescribed for you by your doctor.

Use senna as directed on the label, or as your healthcare provider has prescribed. Do not use this product in larger amounts or for longer than recommended.

Call your healthcare provider if your symptoms do not improve, or if they get worse while using senna. Do not use this product for longer than 1 week without the advice of a healthcare provider.

What should I discuss with my health care provider before taking Pedia-Lax (senna)?

Ask a doctor, pharmacist, herbalist, or other healthcare provider if it is safe for you to use this product if you have:

a bowel disorder such as Crohn's disease or ulcerative colitis;

heart disease; or

stomach pain, nausea, or vomiting.

Before using senna, talk to your doctor, pharmacist, herbalist, or other healthcare provider. You may not be able to use senna if you have any other medical conditions, allergies, or if you take other medicines or herbal/health supplements.

Do not take senna without first talking to your doctor if you are pregnant or could become pregnant. Do not take senna without first talking to your doctor if you are breast-feeding a baby. Some forms of senna are made for use by children. Do not give any herbal/health supplement to a child without the advice of a doctor.

How should I take Pedia-Lax (senna)?

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use senna, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Senna is usually taken before bed to produce a bowel movement 6 to 12 hours later when you wake up.

Do not use different forms (such as tablets and liquid) of senna at the same time unless your healthcare provider tells you to. Call your healthcare provider if your symptoms do not improve, or if they get worse while using senna. Do not use this product for longer than 1 week without the advice of a healthcare provider. Store senna at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Pedia-Lax (senna)?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

Pedia-Lax (senna) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your healthcare provider at once if you have a serious side effect such as:

severe stomach pain, severe diarrhea, watery diarrhea;

weight loss;

worsening constipation after you stop taking senna;

enlargement of your fingers and toes;

low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or

nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

stomach cramps, bloating, gas, mild diarrhea;

numbness or tingly feeling;

joint pain; or

discolored urine.

This is not a complete list of side effects and others may occur. Tell your doctor, pharmacist, herbalist, or other healthcare provider about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Pedia-Lax (senna)?

Do not take senna without the advice of a healthcare provider if you are using any of the following medications:

digoxin (Lanoxin);

a diuretic (water pill); or

a blood thinner such as warfarin (Coumadin).

This list is not complete and other drugs may interact with senna. Tell your healthcare provider about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Pedia-Lax resources

Pedia-Lax Side Effects (in more detail)
Pedia-Lax Use in Pregnancy & Breastfeeding
Pedia-Lax Drug Interactions
Pedia-Lax Support Group
0 Reviews for Pedia-Lax - Add your own review/rating

Senna Natural MedFacts for Professionals (Wolters Kluwer)

Senna Professional Patient Advice (Wolters Kluwer)

Senna Natural MedFacts for Consumers (Wolters Kluwer)

Senna Monograph (AHFS DI)

Senexon Liquid MedFacts Consumer Leaflet (Wolters Kluwer)

Senokot MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Pedia-Lax with other medications

Constipation

Where can I get more information?

Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments.

See also: Pedia-Lax side effects (in more detail)

Wednesday, October 26, 2016

Ampyra

Generic Name: dalfampridine (dal FAM pri deen)

Brand Names: Ampyra

What is dalfampridine?

Dalfampridine is a potassium channel blocker.

Dalfampridine is used to improve walking in patients with multiple sclerosis (MS).

Dalfampridine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about dalfampridine?

You should not use dalfampridine if you are allergic to it, or if you have moderate to severe kidney disease, if you have ever had a seizure (convulsions), or if you are also taking another multiple sclerosis drug called Fampridine.

Before you take dalfampridine, tell your doctor if you have kidney disease.

Do not take more than 2 tablets in a 24-hour period. Do not use a tablet that has been broken or crushed. A broken tablet can release too much of the drug at one time. This can increase your risk of having a seizure. Stop taking dalfampridine and call your doctor at once if you a seizure, pain or burning when you urinate, problems with your balance, numbness or tingly feeling, or a relapse of your MS symptoms.

What should I discuss with my health care provider before taking dalfampridine?

You should not use dalfampridine if you are allergic to it, or if you have:

moderate to severe kidney disease;

if you have ever had a seizure (convulsions); or

if you are also taking another MS drug called Fampridine (4-aminopyridine).

To make sure you can safely take dalfampridine, tell your doctor if you have kidney disease.

FDA pregnancy category C. It is not known whether dalfampridine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.. It is not known whether dalfampridine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using dalfampridine. Do not give this medication to anyone under 18 years old without the advice of a doctor.

How should I take dalfampridine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Dalfampridine is usually taken once every 12 hours. Follow your doctor's instructions.

Do not take more than 2 tablets in a 24-hour period.

Dalfampridine may be taken with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Do not dissolve the tablet in liquid. Breaking or dissolving the pill may cause too much of the drug to be released at one time. Do not use a dalfampridine tablet that has been accidentally crushed or broken. This can increase your risk of having a seizure. Store at room temperature away from moisture and heat.

Throw away any leftover medicine after the expiration date on the label has passed.

See also: Ampyra dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause confusion, problems with thinking or memory, tremors, sweating, or seizures.

What should I avoid while taking dalfampridine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dalfampridine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop taking dalfampridine and call your doctor at once if you have a serious side effect such as:

seizure (convulsions);

pain or burning when you urinate;

problems with balance;

numbness, burning pain, or tingly feeling;

relapse or worsening of MS symptoms;

Less serious side effects may include:

headache, dizziness;

sleep problems (insomnia);

nausea, constipation, upset stomach;

weakness;

stuffy nose, sinus pain, sore throat; or

back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dalfampridine?

There may be other drugs that can interact with dalfampridine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Ampyra resources

Ampyra Side Effects (in more detail)
Ampyra Dosage
Ampyra Use in Pregnancy & Breastfeeding
Ampyra Drug Interactions
Ampyra Support Group
17 Reviews for Ampyra - Add your own review/rating

Ampyra Prescribing Information (FDA)

Ampyra Monograph (AHFS DI)

Ampyra Advanced Consumer (Micromedex) - Includes Dosage Information

Ampyra Consumer Overview

Ampyra MedFacts Consumer Leaflet (Wolters Kluwer)

Dalfampridine Professional Patient Advice (Wolters Kluwer)

Compare Ampyra with other medications

Multiple Sclerosis

Where can I get more information?

Your pharmacist can provide more information about dalfampridine.

See also: Ampyra side effects (in more detail)

Ansaid

Generic Name: flurbiprofen (flure BI proe fen)

Brand Names: Ansaid

What is Ansaid (flurbiprofen)?

Flurbiprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Flurbiprofen works by reducing hormones that cause inflammation and pain in the body.

Flurbiprofen is used to treat pain or inflammation caused by arthritis.

Flurbiprofen may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Ansaid (flurbiprofen)?

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke. Do not use flurbiprofen just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking flurbiprofen, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What should I discuss with my healthcare provider before taking Ansaid (flurbiprofen)?

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use flurbiprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Do not use this medication if you are allergic to flurbiprofen, or if you have:

severe kidney disease; or

a history of allergic reaction to aspirin or other NSAIDs.

If you have any of these other conditions, you may need a flurbiprofen dose adjustment or special tests:

a history of heart attack, stroke, or blood clot;

heart disease, congestive heart failure, high blood pressure;

a history of stomach ulcer or bleeding;

liver or kidney disease;

asthma;

polyps in your nose;

a bleeding or blood clotting disorder; or

if you smoke.

FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking flurbiprofen during the last 3 months of pregnancy may harm the unborn baby. Do not take flurbiprofen during pregnancy unless your doctor has told you to. Flurbiprofen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child without the advice of a doctor.

How should I take Ansaid (flurbiprofen)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

The maximum amount of flurbiprofen for adults is 400 milligrams (mg) per day. Know the amount of flurbiprofen in the specific product you are taking.

If you take flurbiprofen for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled appointments.

Store at room temperature, away from moisture, heat, and light.

See also: Ansaid dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, stomach pain, dizziness, drowsiness, black or bloody stools, coughing up blood, urinating less than usual or not at all, shallow breathing, and fainting.

What should I avoid while taking Ansaid (flurbiprofen)?

Ask a doctor or pharmacist before using any other cold, allergy, or pain medicine. Many medicines available over the counter contain medicines similar to flurbiprofen (such as aspirin, ibuprofen, ketoprofen, or naproxen). Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen. Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Ansaid (flurbiprofen) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking flurbiprofen and seek medical attention or call your doctor at once if you have any of these serious side effects:

chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

urinating less than usual or not at all;

pain, burning, or bleeding when you urinate;

swelling, rapid weight gain;

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

bruising, severe tingling, numbness, pain, muscle weakness.

Less serious side effects may include:

upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas;

dizziness, headache, nervousness;

skin itching or rash;

dry mouth;

increased sweating, runny nose;

blurred vision; or

ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Ansaid (flurbiprofen)?

Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with flurbiprofen may cause you to bruise or bleed easily.

Tell your doctor about all other medicines you use, especially:

a blood thinner such as warfarin (Coumadin;

a diuretic (water pill) such as furosemide (Lasix);

cyclosporine (Gengraf, Neoral, Sandimmune);

lithium (Eskalith, Lithobid);

methotrexate (Rheumatrex, Trexall);

steroids (prednisone and others);

aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others;

an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others; or

a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

This list is not complete and other drugs may interact with flurbiprofen. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Ansaid resources

Ansaid Side Effects (in more detail)
Ansaid Dosage
Ansaid Use in Pregnancy & Breastfeeding
Drug Images
Ansaid Drug Interactions
Ansaid Support Group
2 Reviews for Ansaid - Add your own review/rating

Ansaid Prescribing Information (FDA)

Ansaid MedFacts Consumer Leaflet (Wolters Kluwer)

Ansaid Monograph (AHFS DI)

Ansaid Advanced Consumer (Micromedex) - Includes Dosage Information

Flurbiprofen Professional Patient Advice (Wolters Kluwer)

Flurbiprofen Sodium eent Monograph (AHFS DI)

Compare Ansaid with other medications

Back Pain
Osteoarthritis
Pain
Period Pain
Rheumatoid Arthritis
Sciatica

Where can I get more information?

Your pharmacist can provide more information about flurbiprofen.

See also: Ansaid side effects (in more detail)

Azelastine Nasal

a-ZEL-as-teen

Commonly used brand name(s)

In the U.S.

Astelin

Astelin Ready-Spray

Astepro

Available Dosage Forms:

Spray

Therapeutic Class: Nasal Agent

Pharmacologic Class: Antihistamine

Uses For azelastine

Azelastine nasal spray is used to help relieve symptoms (e.g., stuffy or runny nose, itching, sneezing) of seasonal (short-term) or perennial (year-round) allergic rhinitis (hay fever), and vasomotor rhinitis.

azelastine works by preventing certain cells to release substances that cause the allergic reaction.

azelastine is available only with your doctor's prescription.

Before Using azelastine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For azelastine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to azelastine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of azelastine in children below 12 years of age. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of azelastine have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving azelastine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking azelastine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using azelastine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Cimetidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of azelastine

Use azelastine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects.

azelastine usually comes with patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

azelastine is for use only in the nose. Do not get any of it in your eyes or on your mouth. If it does get on these areas, rinse it off right away.

Before using azelastine, gently blow your nose to clear the nostrils.

To prepare azelastine:

Before you use a new bottle of azelastine spray, the spray pump will need to be primed (started). If your pharmacist assembled the unit for you, check to see if it has already been primed by pumping the unit once. If a full spray comes out, the unit has already been primed; if not you must prime the pump.

To prime a new bottle, hold the bottle upright and away from you, then pump it six times or until you see a fine spray.

If you have not used the spray for 3 or more days, pump it two times or until you see a fine spray.

To keep the applicator clean, wipe the nosepiece with a clean tissue and replace the dust cap after each use.

Dosing

The dose of azelastine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of azelastine. If your dose is different, do not change it unless your doctor tells you to do so.

For nasal dosage form (spray):
- For symptoms of seasonal allergic rhinitis:
  - Adults, teenagers, and children 12 years of age and older—1 or 2 sprays in each nostril two times a day, or 2 sprays in each nostril once a day.
  - Children up to 12 years of age—Use and dose must be determined by your doctor.
- For symptoms of perennial allergic rhinitis:
  - Adults, teenagers, and children 12 years of age and older—2 sprays in each nostril two times a day.
  - Children up to 12 years of age—Use and dose must be determined by your doctor.
- For treatment of vasomotor rhinitis:
  - Adults and teenagers—Use 2 sprays in each nostril two times a day.
  - Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of azelastine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the bottle upright with the pump tightly closed.

Precautions While Using azelastine

Your doctor should check you or your child at regular visits for any problems or unwanted effects that may be caused by azelastine.

azelastine will add to the effects of alcohol and other CNS depressants (medicines that makes you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using azelastine.

azelastine may cause some people to become dizzy, drowsy, or less alert than they are normally. Even if used at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to azelastine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Keep the spray away from the eyes because azelastine may cause irritation or blurred vision. Closing your eyes while you are using azelastine may help keep it out of your eyes.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

azelastine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Blood in the urine

cough

eye pain, eye redness, blurred vision or other change in vision

rapid heartbeat

shortness of breath, tightness in the chest, troubled breathing, or wheezing

skin rash, hives, or itching

sores in the mouth or on the lips

More common

Bitter taste in the mouth

drowsiness or sleepiness

Less common

Bloody mucus or unexplained nosebleeds

burning inside the nose

dizziness

dryness of the mouth

headache

muscle aches or pain

nausea

sore throat

sudden outbursts of sneezing

unusual tiredness or weakness

weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

More azelastine Nasal resources

Azelastine Nasal Use in Pregnancy & Breastfeeding
Azelastine Nasal Drug Interactions
Azelastine Nasal Support Group
23 Reviews for Azelastine Nasal - Add your own review/rating

Astelin Prescribing Information (FDA)

Astelin Consumer Overview

Astelin Spray MedFacts Consumer Leaflet (Wolters Kluwer)

Astepro Prescribing Information (FDA)

Astepro Consumer Overview

Astepro Spray MedFacts Consumer Leaflet (Wolters Kluwer)

Compare azelastine Nasal with other medications

Hay Fever

Adapalene and benzoyl peroxide Topical application

a-DAP-a-leen, BEN-zoe-il per-OX-ide

Commonly used brand name(s)

In the U.S.

Epiduo

Available Dosage Forms:

Gel/Jelly

Therapeutic Class: Antiacne

Chemical Class: Retinoid

Uses For adapalene and benzoyl peroxide

Adapalene and benzoyl peroxide combination is used to treat acne. It works by killing the bacteria that cause acne and by keeping the skin pores clean (tiny openings on the skin).

adapalene and benzoyl peroxide is available only with your doctor's prescription.

Before Using adapalene and benzoyl peroxide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For adapalene and benzoyl peroxide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to adapalene and benzoyl peroxide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of adapalene and benzoyl peroxide combination in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of adapalene and benzoyl peroxide combination in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of adapalene and benzoyl peroxide

It is very important that you use adapalene and benzoyl peroxide only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause your skin to become irritated. You may need to use adapalene and benzoyl peroxide for several weeks or months before your skin starts to look better. Applying extra medicine will not make it work faster.

adapalene and benzoyl peroxide comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

adapalene and benzoyl peroxide is for use on the skin only. Do not get it in your eyes, nose, mouth, or vagina. Do not use it on skin areas that have cuts or scrapes. If it does get on these areas, rinse it off right away.

To use:

Wash your hands with soap and water before and after using adapalene and benzoyl peroxide.

Before applying adapalene and benzoyl peroxide, wash the affected area of your skin with water and a mild soap. Rinse well and pat dry.

Apply a small amount of the medicine to each affected area of the skin (e.g., forehead, chin, cheeks, chest, shoulders), and gently rub it in.

Dosing

The dose of adapalene and benzoyl peroxide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of adapalene and benzoyl peroxide. If your dose is different, do not change it unless your doctor tells you to do so.

For topical dosage form (gel):
- For acne:
  - Adults, teenagers, and children 12 years of age and older—Apply a thin layer to the affected area(s) of the skin once a day.
  - Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of adapalene and benzoyl peroxide, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using adapalene and benzoyl peroxide

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.

adapalene and benzoyl peroxide may make your skin more sensitive to sunlight, wind, and cold weather. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. You may need to wear protective clothing, such as a hat.

Skin reactions such as dryness, redness, scaling, burning, or stinging can occur when you use adapalene and benzoyl peroxide. Use a moisturizer as needed to lessen these skin problems.

Do not use any other medicines on the treated skin areas without asking your doctor. Avoid using any skin care products that can dry or irritate your skin. These include rough skin cleansers, hair removal products, soaps or cosmetics that cause dryness, or products that contain alcohol, astringents, spices, or lime.

Do not use "waxing" as a hair removal method on skin areas treated with adapalene and benzoyl peroxide.

Allow adapalene and benzoyl peroxide to dry completely before getting dressed. adapalene and benzoyl peroxide may cause bleaching of clothes or hair.

adapalene and benzoyl peroxide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Dryness and peeling of the skin

flushing or redness of the skin

unusually warm skin

Less common

Blistering, burning, crusting, or flaking of the skin

burning, itching, redness, skin rash, swelling, or soreness at the application site

scaling, severe redness, or swelling of the skin

Incidence not known

Pain of the skin

sunburn

Incidence not known

Burning, dry, or itching eyes

change in the color of the treated skin

discharge or excessive tearing

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

skin rash, encrusted, scaly, and oozing

swelling of the face

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Compare adapalene and benzoyl peroxide Topical application with other medications

Acne

Precose

Pronunciation: AY-kar-bose
Generic Name: Acarbose
Brand Name: Precose

Precose is used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Precose is a glucosidase inhibitor. It works by slowing down the enzyme that turns carbohydrates into glucose. This results in a smaller rise in blood sugar levels following a meal.

Do NOT use Precose if:

you are allergic to any ingredient in Precose

you have blockage of the stomach or bowel, or you are at risk of these problems

you have inflammatory bowel disease, colon ulcers, or long-term (chronic) stomach or bowel problems that interfere with digestion or nutrient absorption

you have cirrhosis of the liver

you have diabetic ketoacidosis (high ketone levels) or severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Precose:

Some medical conditions may interact with Precose. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have stomach or bowel problems, liver problems or unexplained abnormal liver function tests, or kidney problems

Some MEDICINES MAY INTERACT with Precose. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because the risk of their side effects, including bleeding, may be increased by Precose

Calcium channel blockers (eg, verapamil), corticosteroids (eg, prednisone), diuretics (eg, hydrochlorothiazide), estrogen, isoniazid, nicotinic acid, oral contraceptives (birth control pills), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because they may increase the risk of high blood sugar levels

Insulin or sulfonylureas (eg, glyburide) because they may increase the risk of low blood sugar levels

Oral neomycin because it may increase the risk of Precose's side effects

Digoxin because its effectiveness may be decreased by Precose

This may not be a complete list of all interactions that may occur. Ask your health care provider if Precose may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Precose:

Use Precose as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Precose by mouth at the start (with the first bite) of each main meal.

If you also take charcoal or digestive enzyme preparations (eg, amylase, pancreatin), ask your doctor or pharmacist how to take them with Precose.

Temporary insulin therapy may be necessary during stressful periods (such as fever, infection, surgery, or trauma). Talk with your doctor if any of these occur.

If you miss a dose of Precose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Precose.

Important safety information:

Proper diet and exercise are important in order to lose weight and keep it off. Follow the diet and exercise program given to you by your health care provider.

Diabetes patients - Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Precose exactly as prescribed, tell your doctor.

Tell your doctor or dentist that you take Precose before you receive any medical or dental care, emergency care, or surgery.

Carefully follow the regular testing of urine or blood glucose schedules given to you by your health care provider.

When other diabetes medicines are used with Precose, low blood sugar levels may occur. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. This will raise your blood sugar level quickly. Because Precose prevents the breakdown of table (cane) sugar, be sure to use glucose (dextrose), not sugar or fruits, to treat symptoms of low blood sugar. Contact your health care provider right away if these symptoms occur.

Lab tests, including blood glucose, glycosylated hemoglobin levels, and liver function, may be performed while you use Precose. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Precose should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Precose while you are pregnant. It is not known if Precose is found in breast milk. Do not breast-feed while taking Precose.

Possible side effects of Precose:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloating; diarrhea; gas; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe stomach pain; symptoms of liver problems (eg, dark urine; pale stools; unusual or severe nausea, tiredness, or loss or appetite; yellowing of the skin or eyes).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Precose side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; gas; stomach pain or discomfort.

Proper storage of Precose:

Store Precose below 77 degrees F (25 degrees C) in a tightly sealed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Precose out of the reach of children and away from pets.

General information:

If you have any questions about Precose, please talk with your doctor, pharmacist, or other health care provider.

Precose is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Precose. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Precose resources

Precose Side Effects (in more detail)
Precose Use in Pregnancy & Breastfeeding
Drug Images
Precose Drug Interactions
Precose Support Group
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