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Wednesday, October 26, 2016

Acetaminophen/Pseudoephedrine/Triprolidine

Pronunciation: a-seet-a-MIN-oh-fen/soo-doe-e-FED-rin/try-PRO-li-deen
Generic Name: Acetaminophen/Pseudoephedrine/Triprolidine
Brand Name: Actifed Plus

Acetaminophen/Pseudoephedrine/Triprolidine is used for:

Temporarily relieving symptoms of hay fever, allergies, or the common cold, including pain, fever, nasal congestion, runny nose, sneezing, itching of the nose and throat, and itchy/watery eyes. It may also be used for other conditions as determined by your doctor.

Acetaminophen/Pseudoephedrine/Triprolidine is an analgesic, antihistamine, and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, relieving congestion and pressure. The analgesic works in the brain to reduce pain and fever.

Do NOT use Acetaminophen/Pseudoephedrine/Triprolidine if:

you are allergic to any ingredient in Acetaminophen/Pseudoephedrine/Triprolidine

you are taking droxidopa or sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the past 14 days

you have severe high blood pressure or severe heart disease (eg, coronary artery disease, ischemic heart disease)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Pseudoephedrine/Triprolidine:

Some medical conditions may interact with Acetaminophen/Pseudoephedrine/Triprolidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have glaucoma or increased pressure in the eyes; high blood pressure; diabetes; heart or blood vessel disease; overactive thyroid; seizures; blockage of the stomach, bowel, or bladder; trouble breathing when you sleep; trouble sleeping; a breathing problem (eg, asthma, emphysema, chronic bronchitis); the blood disease porphyria; or an enlarged prostate or prostate disease; or if you have difficulty urinating

if you have a history of liver problems (eg, hepatitis) or severe kidney problems

Some MEDICINES MAY INTERACT with Acetaminophen/Pseudoephedrine/Triprolidine. Tell your health care provider if you are taking any other medicines, especially if any of the following apply to you:

Furazolidone or MAO inhibitors (eg, phenelzine) because side effects such as severe headache, high blood pressure, or high fever may occur

Bromocriptine or sodium oxybate (GHB) because the risk of side effects or toxic effects may be increased by Acetaminophen/Pseudoephedrine/Triprolidine

Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Acetaminophen/Pseudoephedrine/Triprolidine.

Droxidopa because side effects such as irregular heartbeat or heart attack may occur

Urinary alkalinizers (eg, sodium bicarbonate) because the side effects of Acetaminophen/Pseudoephedrine/Triprolidine may be increased

Anticoagulants (eg, warfarin) or isoniazid because the risk of bleeding or liver problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Pseudoephedrine/Triprolidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Pseudoephedrine/Triprolidine:

Use Acetaminophen/Pseudoephedrine/Triprolidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Acetaminophen/Pseudoephedrine/Triprolidine may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

If you miss a dose of Acetaminophen/Pseudoephedrine/Triprolidine and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Pseudoephedrine/Triprolidine.

Important safety information:

Acetaminophen/Pseudoephedrine/Triprolidine may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Acetaminophen/Pseudoephedrine/Triprolidine. Using Acetaminophen/Pseudoephedrine/Triprolidine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Acetaminophen/Pseudoephedrine/Triprolidine. Acetaminophen/Pseudoephedrine/Triprolidine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

Contact your health care provider if symptoms last for more than 7 days or are accompanied by a fever.

Diabetes patients - Acetaminophen/Pseudoephedrine/Triprolidine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

Acetaminophen/Pseudoephedrine/Triprolidine contains pseudoephedrine and acetaminophen. Before you begin taking any new prescription or nonprescription medicine, including medicine used on the skin, read the ingredients to see if it also contains pseudoephedrine or acetaminophen. If it does, or if you are uncertain if it does, contact your doctor or pharmacist.

Do not take diet or appetite control medicines while you are taking Acetaminophen/Pseudoephedrine/Triprolidine without checking with your doctor.

Do not exceed the recommended dose or take Acetaminophen/Pseudoephedrine/Triprolidine for longer than prescribed without checking with your doctor.

If you have trouble sleeping, ask your pharmacist or doctor about the best time of day to take Acetaminophen/Pseudoephedrine/Triprolidine.

Use Acetaminophen/Pseudoephedrine/Triprolidine with caution in the ELDERLY because they may be more sensitive to its effects.

Caution is advised when using Acetaminophen/Pseudoephedrine/Triprolidine in CHILDREN because they may be more sensitive to its effects, especially excitability.

PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking Acetaminophen/Pseudoephedrine/Triprolidine, discuss with your doctor the benefits and risks of using Acetaminophen/Pseudoephedrine/Triprolidine during pregnancy. If you are or will be breast-feeding while you are using Acetaminophen/Pseudoephedrine/Triprolidine, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Acetaminophen/Pseudoephedrine/Triprolidine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability (especially in children); headache; loss of appetite; nausea; nervousness; restlessness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased coordination; difficulty urinating; fast or irregular heartbeat; fever; hallucinations; seizure; severe dizziness and drowsiness; severe nervousness, anxiety, or restlessness; stomach pain; tremors; unusual weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Acetaminophen/Pseudoephedrine/Triprolidine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish-colored skin; difficulty breathing; dilated pupils; fast or irregular heartbeat; fever; flushing; hallucinations; mental or mood changes; seizures; severe drowsiness or dizziness; severe excitability; severe nausea or vomiting; sweating; tremors.

Proper storage of Acetaminophen/Pseudoephedrine/Triprolidine:

Store Acetaminophen/Pseudoephedrine/Triprolidine at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Pseudoephedrine/Triprolidine out of the reach of children and away from pets.

General information:

If you have any questions about Acetaminophen/Pseudoephedrine/Triprolidine, please talk with your doctor, pharmacist, or other health care provider.

Acetaminophen/Pseudoephedrine/Triprolidine is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Acetaminophen/Pseudoephedrine/Triprolidine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Acetaminophen/Pseudoephedrine/Triprolidine resources

Acetaminophen/Pseudoephedrine/Triprolidine Side Effects (in more detail)
Acetaminophen/Pseudoephedrine/Triprolidine Use in Pregnancy & Breastfeeding
Acetaminophen/Pseudoephedrine/Triprolidine Drug Interactions
Acetaminophen/Pseudoephedrine/Triprolidine Support Group
0 Reviews for Acetaminophen/Pseudoephedrine/Triprolidine - Add your own review/rating

Compare Acetaminophen/Pseudoephedrine/Triprolidine with other medications

Cold Symptoms
Hay Fever
Sinus Symptoms

Pitocin

Generic Name: oxytocin (ox e TOW sin)

Brand Names: Pitocin, Syntocinon

What is Pitocin (oxytocin)?

Oxytocin is a natural hormone that causes the uterus to contract.

Oxytocin is used to induce labor, strengthen labor contractions during childbirth, control bleeding after childbirth, or to induce an abortion.

Oxytocin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Pitocin (oxytocin)?

Oxytocin should be administered as an injection into a muscle or intravenously by a healthcare provider. It should be administered in a clinical setting where a healthcare provider can monitor uterine contractions and other vital signs (blood pressure, heart rates) and where an emergency situation can be handled properly.

What should I discuss with my healthcare provider before using Pitocin (oxytocin)?

Do not take oxytocin without first talking to your doctor if you

have or have had cervical cancer;

have an allergy to oxytocin, other medications, dyes, foods, or preservatives;

have eclampsia;

have herpes;

have had more than 7 pregnancies;

are experiencing premature labor;

have had a caesarean section (C-section);

have had any surgery on the cervix or uterus;

have a prolapsed uterus; or

have a breech, placenta previa or any other issues with the fetus or umbilical cord.

You may not be able to use oxytocin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Tell your doctor about all prescription or over-the-counter medicines including vitamins, minerals, and herbal products that your are taking.

Tell your doctor if you drink alcohol or caffeine drinks regularly, if you are a smoker or if you use illegal drugs. These factors can affect the way oxytocin works in your body.

There are no known indications for the use of oxytocin in the first or second trimester of pregnancy other than in relation to spontaneous or induced abortion. Based on the wide experience with this drug and its properties, it would not be expected to present a risk of harm to the baby when used as indicated under the supervision of a trained healthcare professional. Ask your doctor to answer any questions you have about the use of oxytocin and your pregnancy. Do not use oxytocin without first talking to your doctor if you are breast-feeding a baby.

How should I use Pitocin (oxytocin)?

Your healthcare provider will store oxytocin as directed by the manufacturer.

What happens if I miss a dose?

Since the medication will be administered by a healthcare provider, missing a dose should not occur.

What happens if I overdose?

If an overdose of oxytocin is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Oxytocin should be administered in a clinical setting where a healthcare provider can monitor uterine contractions and other vital signs (blood pressure, heart rates) and where an emergency situation can be handled immediately.

What should I avoid while using Pitocin (oxytocin)?

Tell your doctor if you drink alcohol or caffeine drinks regularly, if you are a smoker or if you use illegal drugs. These factors can affect the way oxytocin works in your body.

Pitocin (oxytocin) side effects

Side effects with oxytocin are not common. Serious side effects include:

an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);

difficulty urinating;

chest pain or irregular heart beat;

difficulty breathing;

confusion;

sudden weight gain or excessive swelling;

severe headache;

rash;

excessive vaginal bleeding; or

seizures.

Other, less serious side effects may be more likely to occur. Talk to your doctor if you experience

redness or irritation at the injection site;

loss of appetite; or

nausea or vomiting.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Pitocin (oxytocin)?

Other drugs can interact with oxytocin resulting in dangerous side effects and/or decreased effectiveness. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor during treatment with oxytocin.

More Pitocin resources

Pitocin Side Effects (in more detail)
Pitocin Use in Pregnancy & Breastfeeding
Pitocin Drug Interactions
Pitocin Support Group
0 Reviews for Pitocin - Add your own review/rating

Pitocin MedFacts Consumer Leaflet (Wolters Kluwer)

Pitocin Monograph (AHFS DI)

Pitocin Advanced Consumer (Micromedex) - Includes Dosage Information

Pitocin Prescribing Information (FDA)

Oxytocin Professional Patient Advice (Wolters Kluwer)

Oxytocin Prescribing Information (FDA)

Syntocinon Prescribing Information (FDA)

Compare Pitocin with other medications

Abortion
Labor Induction
Postpartum Bleeding

Where can I get more information?

Your pharmacist has additional information about oxytocin written for health professionals that you may read.

See also: Pitocin side effects (in more detail)

Tuesday, October 25, 2016

Aldoril D50

Generic Name: hydrochlorothiazide and methyldopa (HYE droe KLOR oh THYE a zide and METH il DOE pa)

Brand Names: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50

What is Aldoril D50 (hydrochlorothiazide and methyldopa)?

Methyldopa lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax (widen) and your heart to beat more slowly and easily.

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

The combination of hydrochlorothiazide and methyldopa is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and methyldopa may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Aldoril D50 (hydrochlorothiazide and methyldopa)?

You should not use this medication if you are allergic to methyldopa (Apresoline) or hydrochlorothiazide, if you are unable to urinate, or if you have liver disease (including cirrhosis or hepatitis), or a history of liver problems caused by taking methyldopa. Do not use hydrochlorothiazide and methyldopa if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before using hydrochlorothiazide and methyldopa, tell your doctor if you have kidney disease (or are on dialysis), angina pectoris (chest pain), glaucoma, asthma, gout, lupus, diabetes, an allergy to sulfa drugs or penicillin, or if you have ever had a stroke.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

There are many other drugs that can interact with hydrochlorothiazide and methyldopa. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

What should I discuss with my doctor before taking Aldoril D50 (hydrochlorothiazide and methyldopa)?

Do not use hydrochlorothiazide and methyldopa if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to methyldopa (Apresoline) or hydrochlorothiazide, or if you have:

liver disease (including cirrhosis or hepatitis);

a history of liver problems caused by taking methyldopa; or

if you are unable to urinate.

To make sure you can safely take hydrochlorothiazide and methyldopa, tell your doctor if you have any of these other conditions:

kidney disease (or if you are on dialysis);

angina pectoris (chest pain);

glaucoma;

asthma;

gout;

lupus;

diabetes;

an allergy to sulfa drugs or penicillin; or

if you have ever had a stroke.

FDA pregnancy category C. It is not known whether hydrochlorothiazide and methyldopa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Hydrochlorothiazide and methyldopa can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Aldoril D50 (hydrochlorothiazide and methyldopa)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Your blood pressure will need to be checked often. Your liver function may also need to be tested. Visit your doctor regularly.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and methyldopa. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood and urine may both be tested if you have been vomiting or are dehydrated.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and methyldopa. You may need to stop using the medicine for a short time. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Aldoril D50 (hydrochlorothiazide and methyldopa)?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and methyldopa.

Avoid exposure to sunlight or tanning beds. Hydrochlorothiazide and methyldopa can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Aldoril D50 (hydrochlorothiazide and methyldopa) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using hydrochlorothiazide and methyldopa and call your doctor at once if you have a serious side effect such as:

eye pain, vision problems;

feeling like you might pass out;

chest pain, slow heart rate, feeling short of breath, even with mild exertion;

swelling, rapid weight gain;

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

pale or yellowed skin, dark colored urine, fever, confusion or weakness;

nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

joint pain or swelling with fever, swollen glands, muscle aches, nausea, vomiting, chest pain, unusual thoughts or behavior, and/or seizure (convulsions);

numbness, drooping, or loss of movement in one side of your face;

jerky or rolling muscle movements you cannot control;

high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

urinating less than usual or not at all;

fever, skin rash, bruising, severe tingling, numbness; or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling;severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

stomach cramps, diarrhea, constipation;

depressed mood, trouble concentrating;

joint pain;

muscle pain or weakness;

restless feeling;

dizziness, drowsiness, headache;

soreness or black discoloration of your tongue;

blurred vision; or

impotence, or loss of interest in sex.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Aldoril D50 (hydrochlorothiazide and methyldopa)?

Tell your doctor about all other medicines you use, especially:

cholestyramine (Prevalite, Questran);

colestipol (Colestid);

digoxin (Lanoxin);

insulin or oral diabetes medication;

lithium (Eskalith, LithoBid);

a barbiturate such as phenobarbital (Solfoton);

medicines that contain iron, such as ferrous gluconate (Fergon, Ferralet, Simron), or ferrous sulfate (Chem-Sol, Feosol, Slow Fe, and others);

muscle relaxers or narcotic pain medicine;

steroids (prednisone and others);

other blood pressure medications;

a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

This list is not complete and other drugs may interact with hydrochlorothiazide and methyldopa. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Aldoril D50 resources

Aldoril D50 Side Effects (in more detail)
Aldoril D50 Use in Pregnancy & Breastfeeding
Drug Images
Aldoril D50 Drug Interactions
Aldoril D50 Support Group
0 Reviews for Aldoril D50 - Add your own review/rating

Compare Aldoril D50 with other medications

High Blood Pressure

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and methyldopa.

See also: Aldoril D50 side effects (in more detail)

Adagen

Pronunciation: peg-AD-e-mase BOE-vine
Generic Name: Pegademase Bovine
Brand Name: Adagen

Adagen is used for:

Treating severe combined immunodeficiency disease (SCID) in certain patients with adenosine deaminase (ADA) deficiency.

Adagen is a modified enzyme. It works by correcting the levels of ADA in the body, which improves immune system function.

Do NOT use Adagen if:

you are allergic to any ingredient in Adagen

you have a severely low blood platelet level

Contact your doctor or health care provider right away if any of these apply to you.

Before using Adagen:

Some medical conditions may interact with Adagen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have bleeding, other blood conditions (eg, low blood platelets), or purpura

Some MEDICINES MAY INTERACT with Adagen. Tell your health care provider if you are taking any other medicines, especially any of the following:

2'-deoxycoformycin because it may decrease Adagen's effectiveness

Vidarabine because its effectiveness may be decreased by Adagen

This may not be a complete list of all interactions that may occur. Ask your health care provider if Adagen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Adagen:

Use Adagen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Adagen is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Adagen at home, a health care provider will teach you how to use it. Be sure you understand how to use Adagen. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use Adagen if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Continue to use Adagen even if you feel well. Do not miss any doses.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

If you miss a dose of Adagen, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Adagen.

Important safety information:

Lab tests, including plasma ADA activity and blood cell counts, may be performed while you use Adagen. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Adagen while you are pregnant. It is not known if Adagen is found in breast milk. If you are or will be breast-feeding while you use Adagen, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Adagen:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; pain or redness at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; severe or persistent tiredness or weakness.

See also: Adagen side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Adagen:

Adagen is usually handled and stored by a health care provider. If you are using Adagen at home, store Adagen as directed by your pharmacist or health care provider. Keep Adagen out of the reach of children and away from pets.

General information:

If you have any questions about Adagen, please talk with your doctor, pharmacist, or other health care provider.

Adagen is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Adagen. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Adagen resources

Adagen Side Effects (in more detail)
Adagen Use in Pregnancy & Breastfeeding
Adagen Drug Interactions
Adagen Support Group
0 Reviews for Adagen - Add your own review/rating

Adagen Prescribing Information (FDA)

Adagen Concise Consumer Information (Cerner Multum)

Adagen Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Adagen with other medications

Immunodeficiency

Adapalene and benzoyl peroxide topical

Generic Name: adapalene and benzoyl peroxide (topical) (a DAP a leen and BEN zoyl per OX ide)

Brand names: Epiduo, Epiduo Pump

What is adapalene and benzoyl peroxide topical?

Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect, which allows excess oils and dirt to be easily washed away from the skin.

Adapalene is a medication similar to vitamin A. It helps the skin renew itself.

The combination of adapalene and benzoyl peroxide topical (for the skin) is used to treat acne in people who are at least 12 years old.

Adapalene and benzoyl peroxide topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about adapalene and benzoyl peroxide topical?

Before using this medication, tell your doctor about all other medicated skin products you are using. Using more than one acne medication at a time could cause severe skin irritation.

Avoid getting this medication in your mouth, nose, or eyes, or on your lips. If it does get into any of these areas, rinse with water. Do not use adapalene and benzoyl peroxide topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using adapalene and benzoyl peroxide topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Avoid using skin products that can cause dryness or irritation, such as harsh soaps, shampoos, or skin cleansers, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Do not use other medicated skin products unless your doctor has told you to.

What should I discuss with my healthcare provider before using adapalene and benzoyl peroxide topical?

You should not use this medication if you are allergic to adapalene (Differin) or benzoyl peroxide.

Before using this medication, tell your doctor about all other medicated skin products you are using. Using more than one acne medication at a time could cause severe skin irritation.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before using adapalene and benzoyl peroxide topical, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether adapalene and benzoyl peroxide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use adapalene and benzoyl peroxide topical?

Use adapalene and benzoyl peroxide topical exactly as your doctor has prescribed it for you. Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects. Do not use this medication for longer than your doctor has prescribed.

Wash your hands before and after applying this medication.

Adapalene and benzoyl peroxide topical is usually applied one time per day. Follow your doctor's instructions.

Clean and pat dry the skin to be treated. Use a pea-sized amount of the gel for each treatment area (chin, forehead, and each cheek). Apply the medicine in a thin layer and rub in gently.

Do not apply any other skin products unless your doctor has told you to.

Store adapalene and benzoyl peroxide topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to apply the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of adapalene and benzoyl peroxide applied to the skin is not likely to cause life-threatening symptoms.

What should I avoid while using adapalene and benzoyl peroxide topical?

Avoid getting this medication in your mouth, nose, or eyes, or on your lips. If it does get into any of these areas, rinse with water. Do not use adapalene and benzoyl peroxide topical on sunburned, irritated, or broken skin. Also avoid using adapalene and benzoyl peroxide topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Avoid using skin products that contain salicylic acid, sulfur, or resorcinol while you are using adapalene and benzoyl peroxide topical.

Avoid using skin products that can cause dryness or irritation, such as harsh soaps, shampoos, or skin cleansers, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Avoid exposure to sunlight, sunlamps, or tanning beds. This medication can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

Adapalene and benzoyl peroxide topical side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

During your first 4 weeks of using adapalene and benzoyl peroxide topical, your skin may be dry, red, or scaly. You may also feel some burning or stinging. Call your doctor if these side effects are severe.

Less serious side effects may include mild itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Adapalene and benzoyl peroxide Dosing Information

Usual Adult Dose for Acne:

Adapalene and benzoyl peroxide topical should be applied to affected areas of the face and/or trunk once daily after washing. A pea-size amount is applied to each area of the face (e.g., forehead, chin, each cheek). Avoid the eyes, lips, and mucous membranes.

What other drugs will affect adapalene and benzoyl peroxide topical?

Do not use other medicated skin products unless your doctor has told you to.

It is not likely that other drugs you take orally or inject will have an effect on topically applied adapalene and benzoyl peroxide. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More adapalene and benzoyl peroxide resources

Adapalene and benzoyl peroxide Dosage
Adapalene and benzoyl peroxide Use in Pregnancy & Breastfeeding
Adapalene and benzoyl peroxide Drug Interactions
Adapalene and benzoyl peroxide Support Group
29 Reviews for Adapalene and benzoyl peroxide - Add your own review/rating

Compare adapalene and benzoyl peroxide with other medications

Acne

Where can I get more information?

Your pharmacist can provide more information about adapalene and benzoyl peroxide topical.

Amlodipine and telmisartan

Generic Name: amlodipine and telmisartan (am LOE de peen and TEL me SAR tan)

Brand Names: Twynsta

What is amlodipine and telmisartan?

Amlodipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.

Telmisartan is in a group of drugs called angiotensin II receptor antagonists. Telmisartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of amlodipine and telmisartan is used to treat high blood pressure (hypertension). It is sometimes used together with other blood pressure medications.

Amlodipine and telmisartan may also be used for purposes not listed in this medication guide.

What is the most important information I should know about amlodipine and telmisartan?

Do not use this medicine if you are pregnant. Telmisartan can cause injury or death to the unborn baby if you take this medicine during your second or third trimester. If you become pregnant during treatment, stop using amlodipine and telmisartan and tell your doctor right away.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use potassium supplements or salt substitutes while you are taking amlodipine and telmisartan, unless your doctor has told you to. Call your doctor at once if you have swelling in your hands or feet, rapid weight gain, feeling short of breath, fast or pounding heartbeats, urinating less than usual or not at all, jaundice (yellowing of the skin or eyes), slow heart rate, weak pulse, muscle weakness, tingly feeling, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling, or if you feel like you might pass out. In rare cases, amlodipine and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.

What should I discuss with my healthcare provider before taking amlodipine and telmisartan?

You should not use this medication if you are allergic to amlodipine (Norvasc) or telmisartan (Micardis).

To make sure you can safely take amlodipine and telmisartan, tell your doctor if you have any of these other conditions:

kidney disease (or if you are on dialysis);

liver disease;

congestive heart failure, coronary artery disease;

an electrolyte imbalance;

low blood pressure;

if you are vomiting or having diarrhea; or

if you have recently had a heart attack.

FDA pregnancy category D. Do not use amlodipine and telmisartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking amlodipine and telmisartan. It is not known whether amlodipine and telmisartan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take amlodipine and telmisartan?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take this medication with a full glass (8 ounces) of water.

You may take this medication with or without food.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking amlodipine and telmisartan. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Your heart, liver, and kidney function may also need to be tested. Visit your doctor regularly.

Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Store at room temperature away from moisture and heat.

See also: Amlodipine and telmisartan dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heart rate, warmth or tingling, feeling light-headed, or fainting.

What should I avoid while taking amlodipine and telmisartan?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use potassium supplements or salt substitutes while you are taking amlodipine and telmisartan, unless your doctor has told you to.

Amlodipine and telmisartan side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, amlodipine and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine. Call your doctor at once if you have any other serious side effects, such as:

feeling like you might pass out;

swelling, rapid weight gain, feeling short of breath;

slow heart rate, weak pulse, muscle weakness, tingly feeling;

fast or pounding heartbeats;

urinating less than usual or not at all;

jaundice (yellowing of the skin or eyes); or

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects include:

dizziness, headache, mood changes;

back pain;

change in bowel habits;

stuffy nose, sore throat; or

diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Amlodipine and telmisartan Dosing Information

Usual Adult Dose for Hypertension:

Initial dose: 40/5 to 80/5 mg orally once daily. Dosage should be individualized and may be increased after at least 2 weeks.

Maximum dose: 80/10 mg orally once daily

What other drugs will affect amlodipine and telmisartan?

Tell your doctor about all other medicines you use, especially:

digoxin (Lanoxin);

lithium (Eskalith, LithoBid);

ramipril (Altace);

simvastatin (Zocor, Simcor, Vytorin, Juvisync);

diuretics (water pills);

a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or

other medications that lower blood pressure.

This list is not complete and other drugs may interact with amlodipine and telmisartan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More amlodipine and telmisartan resources

Amlodipine and telmisartan Dosage
Amlodipine and telmisartan Use in Pregnancy & Breastfeeding
Amlodipine and telmisartan Drug Interactions
Amlodipine and telmisartan Support Group
2 Reviews for Amlodipine and telmisartan - Add your own review/rating

Compare amlodipine and telmisartan with other medications

High Blood Pressure

Where can I get more information?

Your pharmacist can provide more information about amlodipine and telmisartan.

Alendronate and cholecalciferol

Generic Name: alendronate and cholecalciferol (a LEN dro nate and KOL e cal SIF er ol)

Brand Names: Fosamax Plus D

What is alendronate and cholecalciferol?

Alendronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures.

Cholecalciferol is a form of vitamin D, and is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Alendronate and cholecalciferol is used to treat and prevent osteoporosis.

Alendronate and cholecalciferol may also be used for purposes not listed in this medication guide.

What is the most important information I should know about alendronate and cholecalciferol?

Do not take an alendronate and cholecalciferol tablet if you cannot sit upright or stand for at least 30 minutes. This medicine can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking the medicine.

Take the alendronate and cholecalciferol tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine.

Take each dose with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking an alendronate and cholecalciferol tablet.

For at least the first 30 minutes after taking this medicine, do not lie down or recline; do not eat or drink anything other than plain water; and do not take any other medicines including vitamins, calcium, or antacids.

Some people using medicines similar to alendronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate and cholecalciferol. You may need to stop using the medicine for a short time.

Talk with your doctor about the risks and benefits of using this medication.

What should I discuss with my healthcare provider before taking alendronate and cholecalciferol?

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:

low blood calcium (hypocalcemia);

a cancer such as sarcoidosis, leukemia, lymphoma;

a vitamin D deficiency;

kidney disease; or

an ulcer in your stomach or esophagus.

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.

Talk with your doctor about the risks and benefits of using this medication.

FDA pregnancy category C. It is not known whether alendronate and cholecalciferol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take alendronate and cholecalciferol?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Alendronate and cholecalciferol tablets are taken once each week. Choose the day of the week that best fits your schedule. Every week, take one alendronate and cholecalciferol tablet on your chosen day.

Take the alendronate and cholecalciferol tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine.

Take the tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking this medicine. Do not crush, chew, or suck the tablet. Swallow the pill whole.

After taking an alendronate and cholecalciferol tablet, carefully follow these instructions:

Do not lie down or recline for at least 30 minutes after taking alendronate and cholecalciferol.

Do not eat or drink anything other than plain water.

Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking alendronate and cholecalciferol. It may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for your other medicines.

To be sure this medication is helping your condition, your bone mineral density will need to be tested on a regular basis. Visit your doctor regularly.

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate and cholecalciferol. You may need to stop using the medicine for a short time.

Alendronate and cholecalciferol is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture and heat.

See also: Alendronate and cholecalciferol dosage (in more detail)

What happens if I miss a dose?

If you forget to take alendronate and cholecalciferol on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly schedule on your chosen dose day. Do not take two (2) tablets in one day.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Drink a full glass of milk and call your local poison control center or emergency room right away. Do not make yourself vomit and do not lie down.

Overdose symptoms may include nausea, heartburn, stomach pain, diarrhea, muscle cramps, numbness or tingling, tight muscles in your face, seizure (convulsions), irritability, and unusual thoughts or behavior.

What should I avoid while taking alendronate and cholecalciferol?

Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking alendronate and cholecalciferol. Do not lie down for at least 30 minutes after you take this medicine.

Alendronate and cholecalciferol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using alendronate and cholecalciferol and call your doctor at once if you have a serious side effect such as:

chest pain;

difficulty or pain when swallowing;

pain or burning under the ribs or in the back;

new or worsening heartburn;

severe joint, bone, or muscle pain;

new or unusual pain in your thigh or hip; or

jaw pain, numbness, or swelling.

Less serious side effects may include:

mild heartburn, nausea, or stomach upset;

diarrhea, gas, or constipation;

mild joint or back pain; or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Alendronate and cholecalciferol Dosing Information

Usual Adult Dose for Osteoporosis:

One tablet orally once weekly. Tablet should only be swallowed upon rising for the day with a full glass of water (6 to 8 ounces) and patients should not lie down for at least 30 minutes and until after their first food of the day.

What other drugs will affect alendronate and cholecalciferol?

Antacids, supplements, or medicines that contain aluminum, calcium, magnesium, or other minerals can interfere with how your body absorbs alendronate and cholecalciferol. If you use these other medicines, do not that take them for at least 30 minutes after taking an alendronate and cholecalciferol tablet.

Before using alendronate and cholecalciferol, tell your doctor if you also use aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as celecoxib (Celebrex), ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.

This list is not complete and other drugs may interact with alendronate and cholecalciferol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More alendronate and cholecalciferol resources

Alendronate and cholecalciferol Side Effects (in more detail)
Alendronate and cholecalciferol Dosage
Alendronate and cholecalciferol Use in Pregnancy & Breastfeeding
Alendronate and cholecalciferol Drug Interactions
Alendronate and cholecalciferol Support Group
0 Reviews for Alendronate and cholecalciferol - Add your own review/rating

Compare alendronate and cholecalciferol with other medications

Osteoporosis

Where can I get more information?

Your pharmacist can provide more information about alendronate and cholecalciferol.

See also: alendronate and cholecalciferol side effects (in more detail)